RAG: a recombinase diversified

被引：40

作者：

Matthews, Adam G. W. ^{[1
,2
]}

Oettinger, Marjorie A. ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 08期

基金：

美国国家卫生研究院;

关键词：

HEAVY-CHAIN GENE; V(D)J RECOMBINATION; B-CELL; HISTONE ACETYLATION; IN-VITRO; IMMUNOGLOBULIN LOCI; GENOMIC INSTABILITY; PLANT HOMEODOMAIN; NUCLEOSOMAL DNA; C-TERMINUS;

D O I：

10.1038/ni.1776

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D) J) recombination. In the past 20 years, a great deal has been learned about the enzymatic activities of the RAG-1-RAG-2 complex. Recent studies have identified several new and exciting regulatory functions of the RAG-1-RAG-2 complex. Here we discuss some of these functions and suggest that the RAG-1-RAG-2 complex nucleates a specialized subnuclear compartment that we call the 'V(D) J recombination factory'.

引用

页码：817 / 821

页数：5

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