Asymmetric Mukaiyama aldol reaction of a ketene silyl acetal of thioester catalyzed by a binaphthol-titanium complex in supercritical fluoroform

被引：28

作者：

Mikami, K ^{[1
]}

Matsukawa, S

Kayaki, Y

Ikariya, T

机构：

[1] Tokyo Inst Technol, Dept Chem Technol, Meguro Ku, Tokyo 1528552, Japan

[2] Japan Sci & Technol Corp, CREST, Meguro Ku, Tokyo 1528552, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 12期

关键词：

Mukaiyama aldol reaction; chiral Ti catalyst; asymmetric catalysis; supercritical fluids;

D O I：

10.1016/S0040-4039(00)00063-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Mukaiyama aldol reaction catalyzed by a binaphthol-derived chiral titanium(IV) complex proceeds smoothly in an unorthodox reaction medium, supercritical fluid (SCF) such as fluoroform (scCHF(3),). The chemical yield and enantioselectivity of the reaction in SCFs are found to be tuned by changing the supercritical fluids, scCHF3 versus carbon dioxide (scCO(2)), and adjusting the matched polarities by varying the pressure of CHF3. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1931 / 1934

页数：4

共 46 条

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