Membrane fusion

被引：157

作者：

Jahn, R

Grubmüller, H

机构：

[1] Max Planck Inst Biophys Chem, Dept Neurobiol, D-37077 Gottingen, Germany

[2] Max Planck Inst Biophys Chem, Theoret Mol Biophys Grp, D-37077 Gottingen, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(02)00356-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fusion of biological membranes is governed by physical principles but it is unclear whether the transition states are primarily determined by lipid physics or by protein-lipid interactions. Recent advances in the field include the physical description of bilayer fusion, particularly new models beyond continuum models and the role of the SNARE proteins. Despite substantial progress, an integrated concept for protein-mediated membrane fusion is not yet available, and many open questions remain to be answered.

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页码：488 / 495

页数：8

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