Nature: A rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy

被引:149
作者
Pandey, Ravindra K.
Goswami, Lalit N.
Chen, Yihui
Gryshuk, Amy
Missert, Joseph R.
Oseroff, Allan
Dougherty, Thomas J.
机构
[1] Roswell Pk Canc Inst, Photodynam Therapy Ctr, Buffalo, NY 14263 USA
[2] Roswell Pk Canc Inst, Dept Nucl Med & Radiol, Buffalo, NY 14263 USA
[3] Roswell Pk Canc Inst, Dept Dermatol, Buffalo, NY 14263 USA
关键词
age related macular degeneration; fluorodeoxyglucose; MRI; PET; PDT;
D O I
10.1002/lsm.20352
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The purpose of this review is to call attention in the use of chlorophyll-a and bacteriochlorophyll-a to develop more than 600 photosensitizers (lambda(max) 660 nm-800 nm) during the last 15 years (1990-2005) at the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo. This article mainly includes the chemistry, preclinical results, and brief clinical data of some of the most effective photosensitizers. The utility of the tumor-avid photosensitizers in developing multimodality agents (imaging and therapy) is also presented.
引用
收藏
页码:445 / 467
页数:23
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