Activated tissue renin-angiotensin systems add to the progression of heart failure

被引：7

作者：

Pinto, YM ^{[1
]}

Buikema, H ^{[1
]}

vanGilst, WH ^{[1
]}

Lie, KI ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT CLIN PHARMACOL,NL-9713 AV GRONINGEN,NETHERLANDS

来源：

BASIC RESEARCH IN CARDIOLOGY | 1996年 / 91卷

关键词：

review-tissue renin-angiotensin systems; heart failure; experimental-clinical;

D O I：

10.1007/BF00795368

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin systems are activated in heart failure; c) activated tissue renin-angiotensin systems induce cardiovascular dysfunction. Finally, this hypothesis predicts that optimal treatment in heart failure requires the inhibition of tissue renin-angiotensin systems. However studies pertaining to this prediction are still lacking, particularly in human subjects.

引用

页码：85 / 90

页数：6

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