Activated tissue renin-angiotensin systems add to the progression of heart failure

被引：7

作者：

Pinto, YM ^{[1
]}

Buikema, H ^{[1
]}

vanGilst, WH ^{[1
]}

Lie, KI ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT CLIN PHARMACOL,NL-9713 AV GRONINGEN,NETHERLANDS

来源：

BASIC RESEARCH IN CARDIOLOGY | 1996年 / 91卷

关键词：

review-tissue renin-angiotensin systems; heart failure; experimental-clinical;

D O I：

10.1007/BF00795368

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin systems are activated in heart failure; c) activated tissue renin-angiotensin systems induce cardiovascular dysfunction. Finally, this hypothesis predicts that optimal treatment in heart failure requires the inhibition of tissue renin-angiotensin systems. However studies pertaining to this prediction are still lacking, particularly in human subjects.

引用

页码：85 / 90

页数：6

共 25 条

[21] SELECTIVE AND TIME-RELATED ACTIVATION OF THE CARDIAC RENIN-ANGIOTENSIN SYSTEM AFTER EXPERIMENTAL HEART-FAILURE - RELATION TO VENTRICULAR-FUNCTION AND MORPHOLOGY [J].

PINTO, YM ;

DESMET, BGJL ;

VANGILST, WH ;

SCHOLTENS, E ;

MONNINK, S ;

DEGRAEFF, PA ;

WESSELING, H .

CARDIOVASCULAR RESEARCH, 1993, 27 (11) :1933-1938

[22]

PINTO YM, 1996, UNPUB EFFECTS HYPERT

[23] INCREASED ANGIOTENSIN-I CONVERTING-ENZYME GENE-EXPRESSION IN THE FAILING HUMAN HEART - QUANTIFICATION BY COMPETITIVE RNA-POLYMERASE CHAIN-REACTION [J].

STUDER, R ;

REINECKE, H ;

MULLER, B ;

HOLTZ, J ;

JUST, H ;

DREXLER, H .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :301-310

[24] SURVIVAL AFTER MYOCARDIAL-INFARCTION IN THE RAT - ROLE OF TISSUE ANGIOTENSIN-CONVERTING ENZYME-INHIBITION [J].

WOLLERT, KC ;

STUDER, R ;

VONBULOW, B ;

DREXLER, H .

CIRCULATION, 1994, 90 (05) :2457-2467

[25]

1987, NEW ENGL J MED, V316, P1429

← 1 2 3 →