The rat as an animal model of Alzheimer's disease

被引：54

作者：

Benedikz, Eirikur ^{[1
]}

Kloskowska, Ewa ^{[1
]}

Winblad, Bengt ^{[2
]}

机构：

[1] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurodegenerat, S-14186 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Kl Alzheimers Dis Res Ctr, S-14186 Stockholm, Sweden

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2009年 / 13卷 / 06期

关键词：

Alzheimer's disease; rat; transgenic; amyloid; cholinergic; BETA-AMYLOID PROTEIN; AMYOTROPHIC-LATERAL-SCLEROSIS; CHOLINERGIC BASAL FOREBRAIN; TRANSGENIC RAT; CONTINUOUS-INFUSION; MEMORY DEFICITS; TRUNCATED TAU; CASCADE HYPOTHESIS; PRECURSOR PROTEIN; OXIDATIVE STRESS;

D O I：

10.1111/j.1582-4934.2009.00781.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

As a disease model, the laboratory rat has contributed enormously to neuroscience research over the years. It has also been a popular animal model for Alzheimer's disease but its popularity has diminished during the last decade, as techniques for genetic manipulation in rats have lagged behind that of mice. In recent years, the rat has been making a comeback as an Alzheimer's disease model and the appearance of increasing numbers of transgenic rats will be a welcome and valuable complement to the existing mouse models. This review summarizes the contributions and current status of the rat as an animal model of Alzheimer's disease.

引用

页码：1034 / 1042

页数：9

共 108 条

[51]

AN INVIVO MODEL FOR THE NEURODEGENERATIVE EFFECTS OF BETA-AMYLOID AND PROTECTION BY SUBSTANCE-P [J].