Molecular pathways in follicular lymphoma

被引：96

作者：

Bende, R. J. ^{[1
]}

Smit, L. A. ^{[1
]}

van Noesel, C. J. M. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

来源：

LEUKEMIA | 2007年 / 21卷 / 01期

关键词：

B-NHL; follicular lymphoma; immunoglobulin; B-cell antigen receptor; cytogenetics; microarray;

D O I：

10.1038/sj.leu.2404426

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Follicular lymphoma (FL) is one of the most common B-cell non-Hodgkin's lymphomas. The initiating genetic event found in similar to 90% of FL is the t(14;18), causing constitutive expression of the antiapoptotic BCL-2 protein. The exact secondary alterations leading to full FL development are still poorly defined. In this review, we address (i) the genetic pathways associated with tumorigenesis and progression of FL, (ii) the role of micro-environmental factors with emphasis on B-cell receptor ligands and (iii) lymphoma models in mice and what they teach us about lymphomagenesis in man.

引用

页码：18 / 29

页数：12

共 156 条

[1] In situ analysis of the variable heavy chain gene of an IgM/IgG-expressing follicular lymphoma -: Evidence for interfollicular trafficking of tumor cells [J].

Aarts, WM ;

Bende, RJ ;

Vaandrager, JW ;

Kluin, PM ;

Langerak, AW ;

Pals, ST ;

van Noesel, CJM .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (03) :883-891

[2] Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time [J].

Aarts, WM ;

Bende, RJ ;

Bossenbroek, JG ;

Pals, ST ;

van Noesel, CJM .

BLOOD, 2001, 98 (01) :238-240

[3] Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load [J].

Aarts, WM ;

Bende, RJ ;

Steenbergen, EJ ;

Kluin, PM ;

Ooms, ECM ;

Pals, ST ;

van Noesel, CJM .

BLOOD, 2000, 95 (09) :2922-2929

[4]

Akasaka H, 2000, CANCER RES, V60, P2335

[5] Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc [J].

Allen, JD ;

Verhoeven, E ;

Domen, J ;

vanderValk, M ;

Berns, A .

ONCOGENE, 1997, 15 (10) :1133-1141

[6]

BAHLER DW, 1991, BLOOD, V78, P1561

[7]

BASTARD C, 1994, BLOOD, V83, P2423

[8] Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity [J].

Bende, RJ ;

Aarts, WM ;

Riedl, RG ;

de Jong, D ;

Pals, ST ;

van Noesel, CJM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (08) :1229-1241

[9] Primary follicular lymphoma of the small intestine -: α4β7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells [J].

Bende, RJ ;

Smit, LA ;

Bossenbroek, JG ;

Aarts, WM ;

Spaargaren, M ;

de Leval, L ;

Boeckxstaens, GEE ;

Pals, ST ;

van Noesel, CJM .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (01) :105-113

[10] Chromosome translocations in multiple myeloma [J].

Bergsagel, PL ;

Kuehl, WM .

ONCOGENE, 2001, 20 (40) :5611-5622

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