β-Catenin hits chromatin: regulation of Wnt target gene activation

被引：460

作者：

Mosimann, Christian ^{[1
]}

Hausmann, George ^{[1
]}

Basler, Konrad ^{[1
]}

机构：

[1] Univ Zurich, Inst Mol Biol, Natl Res Ctr Frontiers Genet, CH-8057 Zurich, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

CRYSTAL-STRUCTURE; TRANSCRIPTIONAL ACTIVATION; SIGNALING PATHWAY; BINDING PROTEIN; IN-VIVO; MEDIATED TRANSCRIPTION; ARMADILLO/BETA-CATENIN; COACTIVATOR PYGOPUS; REMODELING ENZYMES; H3K4; METHYLATION;

D O I：

10.1038/nrm2654

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution to metazoan development, tissue homeostasis and human malignancies. Wnt target gene transcription is regulated by nuclear beta-catenin, and genetic assays have revealed various collaborating protein cofactors. Their daunting number and diverse nature, however, make it difficult to arrange an orderly picture of the nuclear Wnt transduction events. Yet, these findings emphasize that beta-catenin-mediated transcription affects chromatin. How does beta-catenin cope with chromatin regulation to turn on Wnt target genes?

引用

页码：276 / U57

页数：11

共 100 条

[1]

The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation [J].