Behavioral and neuroplastic effects of low-frequency rTMS of the unaffected hemisphere in a chronic stroke patient: A concomitant TMS and fMRI study

被引：29

作者：

Salatino, Adriana ^{[1
]}

Berra, Eliana ^{[2
]}

Troni, Walter ^{[3
]}

Sacco, Katiuscia ^{[1
,4
,5
]}

Cauda, Franco ^{[1
,5
]}

D'Agata, Federico ^{[1
,5
]}

Geminiani, Giuliano ^{[1
,4
,5
]}

Duca, Sergio ^{[5
]}

Dimanico, Ugo ^{[6
]}

Ricci, Raffaella ^{[1
,4
]}

机构：

[1] Univ Turin, Dipartimento Psicol, I-10123 Turin, Italy

[2] Clin San Luca, Serv Neurol & Clin Neurophysiol, Turin, Italy

[3] Univ Turin, Dept Neurol, ASO S Giovanni Battista Molinette, I-10123 Turin, Italy

[4] Univ Turin, NIT, I-10123 Turin, Italy

[5] Koelliker Hosp, CCS fMRI, Turin, Italy

[6] ASL CN1, SSD Serv Neurophysiol, Fossano, Italy

来源：

NEUROCASE | 2014年 / 20卷 / 06期

关键词：

Stroke; rTMS; Functional MRI; Motor recovery; Visual attention; TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; CORTICOSPINAL EXCITABILITY; VISUOSPATIAL NEGLECT; HEMISPATIAL NEGLECT; SUBCORTICAL STROKE; CONTROLLED TRIAL; SPATIAL NEGLECT; ISCHEMIC-STROKE; EXTINCTION;

D O I：

10.1080/13554794.2013.826691

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Repetitive Transcranial Magnetic Stimulation (rTMS) ameliorates motor and neuropsychological deficits following stroke, but little is known about the underlying neuroplasticity. We investigated neuroplastic changes following 5 days of low-frequency rTMS on the intact motor cortex to promote motor recovery in a chronic patient with subcortical stroke. The feasibility of administering multiple treatments was also assessed 6 months later by applying the same protocol over the patient's parietal cortex to improve visuospatial disorders. Behavioral improvements and no adverse events were observed. Neuroimaging findings indicated that motor symptoms amelioration was associated with downregulation and cortical reorganization of hyperactive contralesional hemisphere.

引用

页码：615 / 626

页数：12

共 39 条

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