Programmable Imaging Amplification via Nanoparticle-Initiated DNA Polymerization

被引：8

作者：

Chen, Niancao ^{[2
]}

Li, Shihui ^{[2
]}

Battig, Mark R. ^{[3
]}

Wang, Yong ^{[1
]}

机构：

[1] Penn State Univ, Dept Bioengn, University, PA 16802 USA

[2] Univ Connecticut, Dept Biomed Engn, Storrs, CT 06269 USA

[3] Univ Connecticut, Dept Chem & Biomol Engn, Storrs, CT 06269 USA

来源：

SMALL | 2013年 / 9卷 / 23期

基金：

美国国家科学基金会;

关键词：

HYBRIDIZATION CHAIN-REACTION; EXTRACELLULAR-MATRIX; IN-VIVO; SIGNAL AMPLIFICATION; GOLD NANOPARTICLES; DELIVERY; SENSITIVITY; CONTRAST; INVASION; BIOLOGY;

D O I：

10.1002/smll.201300806

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA growth on nanoparticles: Nanoparticle-mediated molecular recognition and DNA polymerization are integrated for extracellular matrix (ECM) imaging via programmable signal amplification. By using DNA monomers labeled with identical or different imaging reagents, it is promising to achieve single- or multiple-modality imaging of the ECM. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3944 / 3949

页数：6

共 46 条

[1]

ADAMS JC, 1993, DEVELOPMENT, V117, P1183

[2] Pushing the Sensitivity Envelope of Lanthanide-Based Magnetic Resonance Imaging (MRI) Contrast Agents for Molecular Imaging Applications [J].

Aime, Silvio ;

Castelli, Daniela Delli ;

Crich, Simonetta Geninatti ;

Gianolio, Eliana ;

Terreno, Enzo .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (07) :822-831

[3] Assembling materials with DNA as the guide [J].

Aldaye, Faisal A. ;

Palmer, Alison L. ;

Sleiman, Hanadi F. .

SCIENCE, 2008, 321 (5897) :1795-1799

[4] The use of nanocrystals in biological detection [J].

Alivisatos, P .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52

[5]

Almeida JPM, 2011, NANOMEDICINE-UK, V6, P815, DOI [10.2217/NNM.11.79, 10.2217/nnm.11.79]

[6] Multimodality molecular imaging of tumor angiogenesis [J].

Cai, Weibo ;

Chen, Xiaoyuan .

JOURNAL OF NUCLEAR MEDICINE, 2008, 49 :113S-128S

[7] Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks [J].

Cao, Zhiqiang ;

Yu, Qiuming ;

Xue, Hong ;

Cheng, Gang ;

Jiang, Shaoyi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (22) :3771-3776

[8] In Situ Hybridization Chain Reaction Amplification for Universal and Highly Sensitive Electrochemiluminescent Detection of DNA [J].

Chen, Ying ;

Xu, Jin ;

Su, Jiao ;

Xiang, Yun ;

Yuan, Ruo ;

Chai, Yaqin .

ANALYTICAL CHEMISTRY, 2012, 84 (18) :7750-7755

[9] Multimodality Imaging: Beyond PET/CT and SPECT/CT [J].

Cherry, Simon R. .

SEMINARS IN NUCLEAR MEDICINE, 2009, 39 (05) :348-353

[10] Programmable in situ amplification for multiplexed imaging of mRNA expression [J].

Choi, Harry M. T. ;

Chang, Joann Y. ;

Trinh, Le A. ;

Padilla, Jennifer E. ;

Fraser, Scott E. ;

Pierce, Niles A. .

NATURE BIOTECHNOLOGY, 2010, 28 (11) :1208-U103

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