Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks

被引：232

作者：

Cao, Zhiqiang ^{[1
]}

Yu, Qiuming ^{[1
]}

Xue, Hong ^{[1
]}

Cheng, Gang ^{[1
]}

Jiang, Shaoyi ^{[1
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 22期

关键词：

block copolymers; drug delivery; nanoparticles; self-assembly; zwitterions; SELF-ASSEMBLED MONOLAYERS; IN-VIVO; PROTEIN ADSORPTION; POLYMERIC MICELLES; FUNCTIONAL-GROUPS; BLOOD-PLASMA; LIPOSOMES; POLY(L-LYSINE); IMMOBILIZATION; HEPATOCYTES;

D O I：

10.1002/anie.200907079

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

(Figure Presented) In sharp contrast: Poly(carboxybetalne) (PCB)-poly(lactic-co-glycolic acid) (PLGA) block copolymers were obtained by Inclusion of τBu groups onto the PCB monomers. The resulting self-assembled PLGA core/PCB shell nanopartlcles have extraordinary stability and a high potential for functlonallzation because of the COO- groups on the PCB shell (see picture; EDC = l-ethyl-3-(3-dimethylaminopropyl)-carbodiimlde; NHS = N-hydroxysuccinimide). © 2010 Wlley-VCH Verlag GmbH & CO. KCaA.

引用

页码：3771 / 3776

页数：6

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