The molecular basis of somatic hypermutation of immunoglobulin genes

被引：85

作者：

Storb, U

机构：

[1] Dept. Molec. Genet. and Cell Biol., University of Chicago, Chicago, IL 60637

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(96)80059-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.

引用

收藏

页码：206 / 214

页数：9

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