RuvB-Like Protein 2 Is a Suppressor of Influenza A Virus Polymerases

被引：24

作者：

Kakugawa, Satoshi ^{[4
]}

Shimojima, Masayuki ^{[4
]}

Neumann, Gabriele ^{[2
]}

Goto, Hideo ^{[4
]}

Kawaoka, Yoshihiro ^{[1
,2
,3
,4
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo 1088639, Japan

[2] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

[3] Japan Sci & Technol Agcy, Saitama 3320012, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol,Minato Ku, Tokyo 1088639, Japan

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 13期

关键词：

LIVING CELLS; COMPLEX; TRANSCRIPTION; IDENTIFICATION; NUCLEOPROTEIN; REPLICATION; HELICASE; TIP49B; SNORNP;

D O I：

10.1128/JVI.00293-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In pro- and eukaryotic cells, RuvB-like protein 2 (RBL2) resolves Holliday junction recombination intermediates. Here, we identified RBL2 as a suppressor of influenza A virus replication. Human RBL2 appears to interfere with the oligomerization of the viral nucleoprotein, a critical step in the assembly of viral replication complexes.

引用

页码：6429 / 6434

页数：6

共 22 条

[1] Pontin52 and Reptin52 function as antagonistic regulators of β-catenin signalling activity [J].

Bauer, A ;

Chauvet, S ;

Huber, O ;

Usseglio, F ;

Rothbächer, U ;

Aragnol, D ;

Kemler, R ;

Pradel, J .

EMBO JOURNAL, 2000, 19 (22) :6121-6130

[2] TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage [J].

Cho, SG ;

Bhoumik, A ;

Broday, L ;

Ivanov, V ;

Rosenstein, B ;

Ronai, Z .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (24) :8398-8413

[3] Oligomerization of the influenza virus nucleoprotein: Identification of positive and negative sequence elements [J].

Elton, D ;

Medcalf, E ;

Bishop, K ;

Digard, P .

VIROLOGY, 1999, 260 (01) :190-200

[4] Control of transcription by pontin and reptin [J].

Gallant, Peter .

TRENDS IN CELL BIOLOGY, 2007, 17 (04) :187-192

[5] Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complex [J].

Gribun, Anna ;

Cheung, Kevin L. Y. ;

Huen, Jennifer ;

Ortega, Joaquin ;

Houry, Walid A. .

JOURNAL OF MOLECULAR BIOLOGY, 2008, 376 (05) :1320-1333

[6] Drosophila RNAi screen identifies host genes important for influenza virus replication [J].

Hao, Linhui ;

Sakurai, Akira ;

Watanabe, Tokiko ;

Sorensen, Ericka ;

Nidom, Chairul A. ;

Newton, Michael A. ;

Ahlquist, Paul ;

Kawaoka, Yoshihiro .

NATURE, 2008, 454 (7206) :890-U46

[7] Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses [J].

Hatta, M ;

Gao, P ;

Halfmann, P ;

Kawaoka, Y .

SCIENCE, 2001, 293 (5536) :1840-1842

[8] Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis [J].

Hu, CD ;

Kerppola, TK .

NATURE BIOTECHNOLOGY, 2003, 21 (05) :539-545

[9] Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis [J].

Ikura, T ;

Ogryzko, VV ;

Grigoriev, M ;

Groisman, R ;

Wang, J ;

Horikoshi, M ;

Scully, R ;

Qin, J ;

Nakatani, Y .

CELL, 2000, 102 (04) :463-473

[10] TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a [J].

Kanemaki, M ;

Kurokawa, Y ;

Matsu-ura, T ;

Makino, Y ;

Masani, A ;

Okazaki, K ;

Morishita, T ;

Tamura, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (32) :22437-22444

← 1 2 3 →