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The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model

被引：79
作者：
Mylonakis, E
Engelbert, M
Qin, X
Sifri, CD
Murray, BE
Ausubel, FM
Gilmore, MS
Calderwood, SB
机构：
[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
[4] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73190 USA
[5] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73190 USA
[6] Univ Texas, Div Infect Dis, Houston, TX 77030 USA
[7] Univ Texas, Ctr Study Emerging & Reemerging Pathogens, Houston, TX 77030 USA
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 08期
关键词：
D O I：
10.1128/IAI.70.8.4678-4681.2002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.
引用
收藏
页码：4678 / 4681
页数：4
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