Linking albinism and immunity: The secrets of secretory lysosomes

被引：281

作者：

Stinchcombe, J ^{[1
]}

Bossi, G ^{[1
]}

Griffiths, GM ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

SCIENCE | 2004年 / 305卷 / 5680期

关键词：

D O I：

10.1126/science.1095291

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lysosomes are membrane-bound organelles that are found in all mammalian cells and contain hydrolases and lipases required for protein and membrane degradation. In many cells of the immune system, lysosomes also contain secretory proteins that can be released by regulated exocytosis in response to an external stimulus, providing different cell types with a wide range of effector functions. Melanosomes also use a lysosome-related organelle to secrete melanin for pigmentation. Links between albinism and immunity in patients have uncovered a number of key proteins required for lysosomal secretion and have revealed a versatile secretory mechanism that can be fine-tuned by distinct interactions in different cell types.

引用

收藏

页码：55 / 59

页数：5

相关论文

共 74 条

[61] Rab27a is required for regulated secretion in cytotoxic T lymphocytes [J].

Stinchcombe, JC ;

Barral, DC ;

Mules, EH ;

Booth, S ;

Hume, AN ;

Machesky, LM ;

Seabra, MC ;

Griffiths, GM .

JOURNAL OF CELL BIOLOGY, 2001, 152 (04) :825-833

[62] A family of Rab27-binding proteins - Melanophilin links Rab27a and myosin Va function in melanosome transport [J].

Strom, M ;

Hume, AN ;

Tarafder, AK ;

Barkagianni, E ;

Seabra, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) :25423-25430

[63] Mouse models of Hermansky Pudlak Syndrome: A review [J].

Swank, RT ;

Novak, EK ;

McGarry, MP ;

Rusiniak, ME ;

Feng, LJ .

PIGMENT CELL RESEARCH, 1998, 11 (02) :60-80

[64] Abnormal vesicular trafficking in mouse models of Hermansky-Pudlak syndrome [J].

Swank, RT ;

Novak, EK ;

McGarry, MP ;

Zhang, YK ;

Li, W ;

Zhang, Q ;

Feng, LJ .

PIGMENT CELL RESEARCH, 2000, 13 :59-67

[65] A general role for Rab27a in secretory cells [J].

Tolmachova, T ;

Anders, R ;

Stinchombe, J ;

Bossi, G ;

Griffiths, GM ;

Huxley, C ;

Seabra, MC .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (01) :332-344

[66] Activation of lysosomal function during dendritic cell maturation [J].

Trombetta, ES ;

Ebersold, M ;

Garrett, W ;

Pypaert, M ;

Mellman, I .

SCIENCE, 2003, 299 (5611) :1400-1403

[67] Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs [J].

Tucker, WC ;

Weber, T ;

Chapman, ER .

SCIENCE, 2004, 304 (5669) :435-438

[68]

Ward Diane McVey, 2002, Current Molecular Medicine (Hilversum), V2, P469, DOI 10.2174/1566524023362339

[69] Use of expression constructs to dissect the functional domains of the CHS/Beige protein: Identification of multiple phenotypes [J].

Ward, DM ;

Shiflett, SL ;

Huynh, D ;

Vaughn, MB ;

Prestwich, G ;

Kaplan, J .

TRAFFIC, 2003, 4 (06) :403-415

[70] Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis [J].

Waselle, L ;

Coppola, T ;

Fukuda, M ;

Iezzi, M ;

El-Amraoui, A ;

Petit, C ;

Regazzi, R .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (10) :4103-4113

← 1 2 3 4 5 6 7 8 →