Another case of spontaneous regression of Merkel cell (neuroendocrine) carcinoma

BACKGROUND. Merkel cell (neuroendocrine) carcinoma (MCC) is a very aggressive primary cutaneous neoplasm most often occurring on the head and neck of the elderly. Spontaneous regression of MCC was first described in this journal in 1986. Since then, other such cases have been reported. This case represents the sixth case of spontaneous regression of MCC. OBJECTIVE. TO describe to clinical course in a patient with MCC who underwent spontaneous regression of metastatic disease. METHODS. Clinical records including detailed history and frequent follow-up examination made this observation possible. RESULTS. Complete clinically evident regression of metastatic MCC was observed in this case. However, the patient received no treatment known to be effective for MCC. CONCLUSIONS. Spontaneous regression of MCC has been documented. The reason for regression is unknown. Further study of these rare cases may in the future provide more answers than questions. (C) 1997 by the American Society for Dermatologic Surgery, Inc.