Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing Antibodies

被引：133

作者：

Song, Fei ^{[1
]}

Fux, Robert ^{[1
]}

Provacia, Lisette B. ^{[2
]}

Volz, Asisa ^{[1
]}

Eickmann, Markus ^{[3
]}

Becker, Stephan ^{[3
]}

Osterhaus, Albert D. M. E. ^{[2
]}

Haagmans, Bart L. ^{[2
]}

Sutter, Gerd ^{[1
]}

机构：

[1] Univ Munich, Inst Infect Dis & Zoonoses, Munich, Germany

[2] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[3] Univ Marburg, Inst Virol, D-35032 Marburg, Germany

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 21期

关键词：

SARS-COV; RECEPTOR; INFECTION; CELL; DISEASE; FUSION; REGION; ENTRY; EMC;

D O I：

10.1128/JVI.01672-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged as a causative agent of severe respiratory disease in humans. Here, we constructed recombinant modified vaccinia virus Ankara (MVA) expressing full-length MERS-CoV spike (S) protein (MVA-MERS-S). The genetic stability and growth characteristics of MVA-MERS-S make it a suitable candidate vaccine for clinical testing. Vaccinated mice produced high levels of serum antibodies neutralizing MERS-CoV. Thus, MVA-MERS-S may serve for further development of an emergency vaccine against MERS-CoV.

引用

页码：11950 / 11954

页数：5

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