TRAF3: a new component of the TLR-signaling apparatus

被引：35

作者：

Hoebe, Kasper ^{[1
]}

Beutler, Bruce ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, IMM 31, La Jolla, CA 92037 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2006年 / 12卷 / 05期

关键词：

D O I：

10.1016/j.molmed.2006.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) are key sensors of microbially derived molecules that, upon activation, provide a pathogen-specific inflammatory response, leading to an efficient eradication of microbial pathogens. An important question has been how TLRs can provide signaling diversity when challenged with genotypic and functionally distinct pathogens. Recently, two studies have shown that tumor-necrosis factor receptor-associated factor 3 (TRAF3) is an essential component of the TLR-signaling pathway, being a crucial regulator in the induction of TLR-specific inflammatory responses.

引用

页码：187 / 189

页数：3

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