Resolution of inherently chiral 1,4-2,5-calix[8]bis-crown-4 derivatives by enantioselective HPLC

被引：25

作者：

Caccamese, S

Principato, G

Geraci, C

Neri, P

机构：

[1] CNR,IST STUD SOSTAN NAT INTER ALIMENTARE & CHIM FARM,I-95028 VALVERDE,CT,ITALY

[2] UNIV CATANIA,DIPARTIMENTO SCI CHIM,I-95125 CATANIA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(97)00115-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first example of the resolution of inherently chiral calix[8]arenes, 1,4-2,5-calix[8]bis-crown-4 1 and its methyl derivatives 2-4, has been achieved using enantioselective HPLC methods. The enantiomeric nature of isolated (+)-1 and (-)-1 was confirmed by CD spectra, specific optical rotation and H-1 NMR in the presence of Pirkle's reagent. A rationale is given for the observed HPLC enantioselectivity among compounds 2-4. (C) 1997 Elsevier Science Ltd.

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页码：1169 / 1173

页数：5

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