Membrane lipids and cell death: an overview

被引:67
作者
Cristea, IM
Degli Esposti, M
机构
[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
[2] Rockefeller Univ, Lab Mass Spectrometry & Gaseous Ion Chem, New York, NY USA
关键词
phospholipids; apoptosis; mitochondria; bcl-2; lipidomics; membrane traffic;
D O I
10.1016/j.chemphyslip.2004.02.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this article we overview major aspects of membrane lipids in the complex area of cell death, comprising apoptosis and various forms of programmed cell death. We have focused here on glycerophospholipids, the major components of cellular membranes. In particular, we present a detailed appraisal of mitochondrial lipids that attract increasing interest in the field of cell death. while the knowledge of their re-modelling and traffic remains limited. It is hoped that this review will stimulate further studies by lipid experts to fully elucidate various aspects of membrane lipid homeostasis that are discussed here. These studies will undoubtedly reveal new and important connections with the established players of cell death and their action in promoting or blocking membrane alteration of mitochondria and other organelles. We conclude that the new dynamic era of cell death research will pave the way for a better understanding of the 'chemistry of apoptosis'. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:133 / 160
页数:28
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