Synthesis of water-soluble oxidized chitosan derivatives and their biological activity

被引：34

作者：

Terada, N ^{[1
]}

Morimoto, M

Saimoto, H

Okamoto, Y

Minami, S

Shigemasa, Y

机构：

[1] TAKI Chem Co Ltd, Kakogawa 6750125, Japan

[2] Tottori Univ, Fac Agr, Dept Vet Surg, Tottori 6808553, Japan

[3] Tottori Univ, Fac Engn, Dept Mat Sci, Tottori 6808552, Japan

来源：

CHEMISTRY LETTERS | 1999年 / 12期

关键词：

D O I：

10.1246/cl.1999.1285

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidized chitosan derivatives were prepared by CrO3 oxidation of chitosan followed by N-acetylation, and their effect on canine polymorphonuclear cells was evaluated. The water-solubility of oxidized chitosan derivatives (DS: 0.10-0.28) in the range of pH 1-13 was controlled by the degree of N-acetylation (DA), and the oxidized chitosan derivatives of DA 76 and 83% were soluble in water at the neutral pH range. Effect of oxidized chitosan derivatives on canine polymorphonuclear cells (PMNs) was estimated by the reported chemiluminescence (CL) technique, and the peak count of CL induced by zymosan after the treatment of PMNs with oxidized chitosan derivatives was lower than that induced by only zymosan.

引用

页码：1285 / 1286

页数：2

共 10 条

[1]

[Anonymous], BIOTECHNOL GEN ENG R

[2] Oxidation of primary alcohol groups of naturally occurring polysaccharides with 2,2,6,6-tetramethyl-1-piperidine oxoammonium ion [J].