Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression

被引：160

作者：

Young, LT ^{[1
]}

Joffe, RT ^{[1
]}

Robb, JC ^{[1
]}

MacQueen, GM ^{[1
]}

Marriott, M ^{[1
]}

Patelis-Siotis, I ^{[1
]}

机构：

[1] Hamilton Psychiat Hosp, Mood Disorders Program, Hamilton, ON L8N 3K7, Canada

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2000年 / 157卷 / 01期

关键词：

D O I：

10.1176/ajp.157.1.124

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: This study's purpose was to clarify the appropriate treatment of bipolar depression by comparing the addition of an antidepressant versus a second mood stabilizer for inpatients being treated with lithium carbonate or divalproex sodium. Method: Twenty-seven patients were randomly assigned to groups that received double-blind treatment with paroxetine or a second mood stabilizer (lithium carbonate or divalproex sodium) for 6 weeks. Results: Both groups showed significant improvement in depressive symptoms during the 6-week trial. There were significantly more noncompleters in the group being treated with the two mood stabilizers than in the group being treated with a mood stabilizer and paroxetine. Conclusions: Both treatments appeared to be effective; however, the addition of an antidepressant may have greater clinical utility in the treatment of bipolar depression.

引用

页码：124 / 126

页数：3