Trafficking of G protein-coupled receptors

被引:250
作者
Drake, Matthew T.
Shenoy, Sudha K.
Lefkowitz, Robert J.
机构
[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA
关键词
GPCR; trafficking; GPCR kinase (GRK); beta-arrestin; 7-transmembrane receptors;
D O I
10.1161/01.RES.0000242563.47507.ce
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.
引用
收藏
页码:570 / 582
页数:13
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