Remarkable activity of a novel cyclic seleninate ester as a glutathione peroxidase mimetic and its facile in situ generation from allyl 3-hydroxypropyl selenide

被引：129

作者：

Back, TG ^{[1
]}

Moussa, Z ^{[1
]}

机构：

[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 41期

关键词：

D O I：

10.1021/ja028030k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1,2-Oxaselenolane Se-oxide is a novel cyclic seleninate ester that functions as a remarkably efficient glutathione peroxidase mimetic by catalyzing the reduction of tert-butyl hydroperoxide to tert-butyl alcohol in the presence of benzyl thiol. The seleninate ester can be conveniently generated in situ by oxidation of allyl 3-hydroxypropyl selenide with tert-butyl hydroperoxide. Its catalytic activity surpasses that of several other known GPx mimetics containing cyclic selenenamide structures, which were also tested for comparison. Copyright © 2002 American Chemical Society.

引用

页码：12104 / 12105

页数：2

共 36 条

[31]

Pryor W.A., 1976, FREE RADICALS BIOL, VI

[32] SELENOXIDES OF D-XYLOSE AND D-RIBOSE DERIVATIVES [J].