Neural stem cell therapies for enteric nervous system disorders

被引：80

作者：

Burns, Alan J. ^{[1
,2
]}

Thapar, Nikhil ^{[1
,2
,3
]}

机构：

[1] UCL Inst Child Hlth, Birth Defects Res Ctr, Neural Dev Unit, London WC1N 1EH, England

[2] UCL Inst Child Hlth, Birth Defects Res Ctr, Gastroenterol Unit, London WC1N 1EH, England

[3] Great Ormond St Hosp Sick Children, Dept Paediat Gastroenterol, Div Neurogastroenterol & Motil, London WC1N 3JH, England

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2014年 / 11卷 / 05期

关键词：

NITRIC-OXIDE SYNTHASE; GASTROINTESTINAL NEUROMUSCULAR PATHOLOGY; HYPERTROPHIC PYLORIC-STENOSIS; CHRONIC INTESTINAL PSEUDOOBSTRUCTION; INTERSTITIAL-CELLS; MYENTERIC PLEXUS; PROGENITOR CELLS; HIRSCHSPRUNGS-DISEASE; INTRINSIC DIFFERENCES; NEURONAL DYSPLASIA;

D O I：

10.1038/nrgastro.2013.226

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The enteric nervous system is vulnerable to a range of congenital and acquired disorders that disrupt the function of its neurons or lead to their loss. The resulting enteric neuropathies are some of the most challenging clinical conditions to manage. Neural stem cells offer the prospect of a cure given their potential ability to replenish missing or dysfunctional neurons. This article discusses diseases that might be targets for stem cell therapies and the barriers that could limit treatment application. We explore various sources of stem cells and the proof of concept for their use. The critical steps that remain to be addressed before these therapies can be used in patients are also discussed. Key milestones include the harvesting of neural stem cells from the human gut and the latest in vivo transplantation studies in animals. The tremendous progress in the field has brought experimental studies exploring the potential of stem cell therapies for the management of enteric neuropathies to the cusp of clinical application.

引用

页码：317 / 328

页数：12

共 132 条

[1]

Characterisation and transplantation of enteric nervous system progenitor cells [J].

Almond, Sarah ;

Lindley, Richard M. ;

Kenny, Simon E. ;

Connell, M. Gwen ;

Edgar, David H. .

GUT, 2007, 56 (04) :489-496

[2]

Hirschsprung disease, associated syndromes, and genetics: a review [J].

Amiel, J ;

Lyonnet, S .

JOURNAL OF MEDICAL GENETICS, 2001, 38 (11) :729-739

[3]

[Anonymous], 2006, The Enteric Nervous System Oxford

[4]

Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET [J].

Barlow, A ;

de Graaff, E ;

Pachnis, V .

NEURON, 2003, 40 (05) :905-916

[5]

Slow transit constipation: A functional disorder becomes an enteric neuropathy [J].

Bassotti, Gabrio ;

Villanacci, Vincenzo .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (29) :4609-4613

[6]

Ex Vivo Neurogenesis within Enteric Ganglia Occurs in a PTEN Dependent Manner [J].

Becker, Laren ;

Peterson, Johann ;

Kulkarni, Subhash ;

Pasricha, Pankaj Jay .

PLOS ONE, 2013, 8 (03)

[7]

Divergent fate and origin of neurosphere-like bodies from different layers of the gut [J].

Becker, Laren ;

Kulkarni, Subhash ;

Tiwari, Gunjan ;

Micci, Maria-Adelaide ;

Pasricha, Pankaj Jay .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 302 (09) :G958-G965

[8]

The tumorigenicity of human embryonic and induced pluripotent stem cells [J].

Ben-David, Uri ;

Benvenisty, Nissim .

NATURE REVIEWS CANCER, 2011, 11 (04) :268-277

[9]

Prevalence and burden based study in women [J].

Bharucha, AE ;

Zinsmeister, AR ;

Locke, GR ;

Seide, BM ;

McKeon, K ;

Schleck, CD ;

Melton, LJ .

GASTROENTEROLOGY, 2005, 129 (01) :42-49

[10]

Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity [J].

Bixby, S ;

Kruger, GM ;

Mosher, JT ;

Joseph, NM ;

Morrison, SJ .

NEURON, 2002, 35 (04) :643-656

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