Using photolabile ligands in drug discovery and development

被引：336

作者：

Dormán, G

Prestwich, GD

机构：

[1] ComGenex, H-1027 Budapest, Hungary

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2000年 / 18卷 / 02期

关键词：

D O I：

10.1016/S0167-7799(99)01402-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Photoactivatable ligands are important tools used in drug discovery and drug development. These ligands enable researchers to identify the targets of drugs, to determine the affinity and selectivity of the drug-target interaction, and to identify the binding site on the target. Examples are presented from three fundamentally different approaches: (1) photoaffinity labeling of target macromolecules; (2) photoactivation and release of 'caged' ligands; and (3) photoimmobilization of ligands onto surfaces.

引用

收藏

页码：64 / 77

页数：14

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