A light-inactivated antibiotic

被引：37

作者：

Lee, WL ^{[1
]}

Li, ZH ^{[1
]}

Vakulenko, S ^{[1
]}

Mobashery, S ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 43卷 / 01期

关键词：

D O I：

10.1021/jm980648a

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sodium 7 beta-[(R)-2-(N-b-o-nitrobenzyloxycarbonyl)hydrazino-3-phenylpropanamido]cephalosporanate (1) is described as a new type of beta-lactam antibiotic, which undergoes light-induced destruction of its beta-lactam moiety and hence becomes biologically inactive. This type of antibiotic holds the promise of self-destruction over a number of hours of exposure to light, so that it would not allow selection of resistance in the environment.

引用

页码：128 / 132

页数：5

共 29 条

[11] AMMONOLYSIS OF CEPHAMYCINS - C-13 NMR CHARACTERIZATION OF THE INTERMEDIATES FROM BETA-LACTAM RING CLEAVAGE PRIOR TO LOSS OF THE 3'-GROUP [J].