Anti-Heat Shock Protein 27 Antibody Levels and Diabetes Complications in the EURODIAB Study

被引：12

作者：

Burt, Davina ^{[1
]}

Bruno, Graziella ^{[1
]}

Chaturvedi, Nish ^{[2
]}

Schalkwijk, Casper ^{[3
]}

Stehouwer, Coen D. ^{[3
]}

Witte, Daniel R. ^{[4
]}

Fuller, John H. ^{[5
]}

Pinach, Silvia ^{[1
]}

Perin, Paolo Cavallo ^{[1
]}

Gruden, Gabriella ^{[1
]}

机构：

[1] Univ Turin, Dept Internal Med, Turin, Italy

[2] Imperial Coll Sch Med, Natl Heart & Lung Inst, London, England

[3] Maastrict Univ, Med Ctr, Dept Internal Med, Maastricht, Netherlands

[4] Steno Diabet Ctr, Epidemiol Res Grp, DK-2820 Gentofte, Denmark

[5] Royal Free & Univ Coll London, Dept Epidemiol & Publ Hlth, Sch Med, London, England

来源：

DIABETES CARE | 2009年 / 32卷 / 07期

关键词：

RISK-FACTORS; HEAT-SHOCK-PROTEIN-27; TITERS;

D O I：

10.2337/dc08-2271

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To assess whether serum anti-heat shock protein 27 (HSP27) antibody levels are associated with micro- and macrovascular complications of type I diabetes. RESEARCH DESIGN AND METHODS - Anti-HSP27 IgG antibody levels were measured in 531 type 1 diabetic subjects recruited as part of the cross-sectional analysis of the EURODIAB Prospective Complications Study. Case Subjects (n = 363) were defined as individuals With one or more diabetes complications and control subjects (n = 168) as individuals with no evidence of any diabetes Complication, RESULTS - Anti-HSP27 levels were comparable in case and control subjects (19.6 arbitrary units/ml [11.3-32.7] vs. 20.4 arbitrary units/ml [11.7-35.3], geometric mean [interquartile range]), and there was no correlation between HSP27 and anti-HSP27 levels (r = 0.01 P = 0.81). In logistic regression analysis, anti-HSP27 was not associated with the presence of complications, even after adjustment for main risk factors. CONCLUSIONS - Anti-HSP27 antibody levels are not a marker of vascular complications in type I diabetes.

引用

页码：1269 / 1271

页数：3

共 11 条

[1] Circulating and urinary transforming growth factor β1, Amadori albumin, and complications of type 1 diabetes -: The EURODIAB Prospective Complications Study [J].