Heat shock protein 27: its potential role in vascular disease

被引：93

作者：

Ferns, Gordon ^{[1
]}

Shams, Sedigheh

Shafi, Shahida

机构：

[1] Univ Surrey, Sch Biomed & Mol Sci, Ctr Clin Sci & Measurement, Guildford GU2 7XH, Surrey, England

[2] Royal Surrey Cty Hosp, Guildford, Surrey, England

[3] Univ Tehran Med Sci, Fac Med, Dept Pathol, Childrens Med Ctr, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY | 2006年 / 87卷 / 04期

关键词：

apoptosis; atherosclerosis; chaperonin; Hsp27; vascular cells;

D O I：

10.1111/j.1365-2613.2006.00484.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Heat shock proteins are molecular chaperones that have an ability to protect proteins from damage induced by environmental factors such as free radicals, heat, ischaemia and toxins, allowing denatured proteins to adopt their native configuration. Heat shock protein-27 (Hsp27) is a member of the small Hsp (sHsp) family of proteins, and has a molecular weight of approximately 27 KDa. In addition to its role as a chaperone, it has also been reported to have many additional functions. These include effects on the apoptotic pathway, cell movement and embryogenesis. In this review, we have focused on its possible role in vascular disease.

引用

页码：253 / 274

页数：22

共 188 条

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