The genetic and molecular regulation of sleep: from fruit flies to humans

被引：237

作者：

Cirelli, Chiara ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CEREBRAL PROTEIN-SYNTHESIS; FATAL FAMILIAL INSOMNIA; RESTLESS-LEGS-SYNDROME; EYE-MOVEMENT SLEEP; NON-CIRCADIAN ROLE; DROSOPHILA-MELANOGASTER; PRION PROTEIN; POTASSIUM CHANNELS; INDIVIDUAL-DIFFERENCES; ELECTROENCEPHALOGRAPHIC FINGERPRINT;

D O I：

10.1038/nrn2683

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been known for a long time that genetic factors affect sleep quantity and quality. Genetic screens have identified several mutations that affect sleep across species, pointing to an evolutionary conserved regulation of sleep. Moreover, it has also been recognized that sleep affects gene expression. These findings have given valuable insights into the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders.

引用

页码：549 / 560

页数：12

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