4-cyanothiazolidides as very potent, stable inhibitors of dipeptidyl peptidase IV

被引：27

作者：

Ashworth, DM ^{[1
]}

Atrash, B ^{[1
]}

Baker, GR ^{[1
]}

Baxter, AJ ^{[1
]}

Jenkins, PD ^{[1
]}

Jones, DM ^{[1
]}

Szelke, M ^{[1
]}

机构：

[1] FERRING RES INST,CHILWORTH RES CTR,SOUTHAMPTON SO16 7NP,HANTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00491-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of stable, very potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 4-cyanothiazolidide were found to have K-i values of less than 1 nM versus human DP-IV and half-lives of between 5 and 27h in aqueous solution (pH 7.4). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2745 / 2748

页数：4

共 8 条

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