Recent progress in the synthesis of 1,2,3,4-tetrahydroquinolines

被引：714

作者：

Katritzky, AR

Rachwal, S

Rachwal, B

机构：

[1] Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville

来源：

TETRAHEDRON | 1996年 / 52卷 / 48期

关键词：

D O I：

10.1016/S0040-4020(96)00911-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Many good synthetic methods for 1,2,3,4-tetrahydroquinolines bearing substituents on the heterocyclic ring have been recently developed. The nature, number and relative location of the substituents are the key parameters to consider before choosing a method. Recommended synthetic methods are summarized in the Table. Benzotriazole methodology is frequently the best method for making 3-monosubstituted 4-monosubstituted and 3,4-disubstituted tetrahydroquinolines. Substitution at the nitrogen atom and at the aromatic ring, not considered in this review, may also influence the choice of the optimum method.

引用

收藏

页码：15031 / 15070

页数：40

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