Anti-allergic effects of Cnidii Monnieri Fructus (Dried fruits of Cnidium monnieri) and its major component, osthol

被引:136
作者
Matsuda, H
Tomohiro, N
Ido, Y
Kubo, M
机构
[1] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan
[2] Kinki Univ, Fac Pharmaceut Sci, Med Herb Garden, Higashiosaka, Osaka 5778502, Japan
关键词
Cnidii Monnieri Fructus; Cnidium monnieri; osthol; anti-allergic effect; antipruritic effect;
D O I
10.1248/bpb.25.809
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl chloride (PC)-induced contact dermatitis in experimental animals. CM-ext showed inhibitory effects. on these allergic models. Osthol isolated from CM-ext also had the inhibitory effects. These results suggested that Cnidii Monnieri Fructus might be useful as an agent for allergic diseases and that its anti-allergic effect was partially attributable to a coumarin derivative, osthol.
引用
收藏
页码:809 / 812
页数:4
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