Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1

被引：11

作者：

Diallo, K

Oliveira, M

Moisi, D

Brenner, B

Wainberg, MA

Götte, M

机构：

[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, McGill AIDS Ctr, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3T 1E2, Canada

[3] McGill Univ, Dept Expt Med, Montreal, PQ H3T 1E2, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 07期

关键词：

D O I：

10.1128/AAC.46.7.2254-2256.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.

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页码：2254 / 2256

页数：3

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