Long-Term Small Molecule and Protein Elution from TiO2 Nanotubes

被引：179

作者：

Peng, Lily ^{[1
,2
]}

Mendelsohn, Adam D. ^{[1
,2
]}

LaTempa, Thomas J. ^{[3
,4
]}

Yoriya, Sorachon ^{[3
,4
]}

Grimes, Craig A. ^{[3
,4
]}

Desai, Tejal A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA

[4] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 05期

基金：

美国国家科学基金会;

关键词：

TITANIA NANOTUBES; FABRICATION; TACROLIMUS; ARRAYS;

D O I：

10.1021/nl9001052

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, TiO2 nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO2 nanotubes may be a promising candidate for a drug-eluting implant coating.

引用

页码：1932 / 1936

页数：5

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