Chimeric (aeg-pyrrolidine)PNAs:: synthesis and stereo-discriminative duplex binding with DNA/RNA

被引：10

作者：

Lonkar, PS ^{[1
]}

Ganesh, KN ^{[1
]}

Kumar, VA ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 18期

关键词：

D O I：

10.1039/b407292h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design and facile conversion of naturally occurring 4-hydroxyproline to all four diastereomers of thymine pyrrolidine PNA monomer, (2R, 4S)-adenine, -guanine and -cytosine monomers and their incorporation into duplex forming PNA oligomers is reported. The interesting results of the hybridization studies with complementary DNA/RNA sequences in either parallel or antiparallel orientation reveal the stereochemistry-dependent DNA vs. RNA discriminations and parallel/ antiparallel orientation selectivity.

引用

页码：2604 / 2611

页数：8

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