Aminoethylprolyl peptide nucleic acids (aepPNA):: Chiral PNA analogues that form highly stable DNA:aepPNA2 triplexes

被引：70

作者：

D'Costa, M ^{[1
]}

Kumar, VA ^{[1
]}

Ganesh, KN ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem Synth, Poona 411008, Maharashtra, India

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 10期

关键词：

D O I：

10.1021/ol990835i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The replacement of the glycyl component in the peptide nucleic acid (PNA) backbone by a prolyl unit bearing a nucleobase leads to the aminoethylprolyl (aep) PNAs, which are chiral and cationic. The homooligomeric aepPNA binds to complementary DNA sequences with high affinity and sequence specificity, forming highly stable triplexes.

引用

页码：1513 / 1516

页数：4

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