C-Mannose derivatives as potent mimics of sialyl Lewis X

被引：45

作者：

Marron, TG

Woltering, TJ

WeitzSchmidt, G

Wong, CH

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

[2] SANDOZ PHARMACEUT LTD, PRECLIN RES, CH-4002 BASEL, SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(96)02124-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of five sialyl Lewis X mimetics was described. Mimetics 2 - 6 were easily synthesized from readily available starting materials. Mimics 4 and 6 showed activities five-fold better than sialyl Lewis X. Copyright (C) 1996 Elsevier Science Ltd

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页码：9037 / 9040

页数：4

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