Glycomimetic selectin inhibitors: (alpha-D-mannopyranosyloxy)methylbiphenyls

被引：33

作者：

Dupre, B

Bui, H

Scott, IL

Market, RV

Keller, KM

Beck, PJ

Kogan, TP

机构：

[1] TEXAS BIOTECHNOL CORP,DEPT MED CHEM,HOUSTON,TX 77030

[2] TEXAS BIOTECHNOL CORP,DEPT IMMUNOL & MOL BIOL,HOUSTON,TX 77030

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/0960-894X(96)00071-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of biphenyl-based compounds were investigated for their ability to inhibit sialyl Lewis X (sLe(x)) dependent binding of HL-60 cells to E- and P-selectin fusion proteins. Compounds (26) and (2h) demonstrated improved binding as compared to both the natural ligand sLe(x) and a previously reported inhibitor TBC-265 (1, R = 3-CH2CO2H).

引用

页码：569 / 572

页数：4

共 20 条

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