aldol reaction;
diastereoselectivity;
epoxidation;
natural products;
total synthesis;
D O I:
10.1002/anie.200353348
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Two stereoselective aldol reactions, a nitrile oxide cycloaddition, and a stereoselective late-stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these compounds.