Total synthesis and stereochemical assignment of myriaporones 1, 3, and 4

被引:41
作者
Fleming, KN [1 ]
Taylor, RE [1 ]
机构
[1] Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA
关键词
aldol reaction; diastereoselectivity; epoxidation; natural products; total synthesis;
D O I
10.1002/anie.200353348
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two stereoselective aldol reactions, a nitrile oxide cycloaddition, and a stereoselective late-stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these compounds.
引用
收藏
页码:1728 / 1730
页数:3
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