Total synthesis and stereochemical assignment of myriaporones 1, 3, and 4

被引：41

作者：

Fleming, KN ^{[1
]}

Taylor, RE ^{[1
]}

机构：

[1] Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 13期

关键词：

aldol reaction; diastereoselectivity; epoxidation; natural products; total synthesis;

D O I：

10.1002/anie.200353348

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two stereoselective aldol reactions, a nitrile oxide cycloaddition, and a stereoselective late-stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these compounds.

引用

页码：1728 / 1730

页数：3

共 24 条

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