Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma

被引：364

作者：

Chai, Zhilan ^{[1
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,3
,4
,5
]}

Ran, Danni ^{[1
,2
,3
,4
,5
]}

Lu, Linwei ^{[9
,10
]}

Zhan, Changyou ^{[1
,2
,3
,4
,5
,6
,11
]}

Ruan, Huitong ^{[1
,2
,3
,4
,5
]}

Hu, Xuefeng ^{[1
,2
,3
,4
,5
]}

Xie, Cao ^{[1
,2
,3
,4
,5
]}

Jiang, Kuan ^{[1
,2
,3
,4
,5
]}

Li, Jinyang ^{[1
,2
,3
,4
,5
]}

Zhou, Jianfen ^{[1
,2
,3
,4
,5
]}

Wang, Jing ^{[1
,2
,3
,4
,5
]}

Zhang, Yanyu ^{[1
,2
,3
,4
,5
]}

Fang, Ronnie H. ^{[7
,8
]}

Zhang, Liangfang ^{[7
,8
]}

Lu, Weiyue ^{[1
,2
,3
,4
,5
,12
,13
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China

[2] Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China

[3] Fudan Univ, PLA, Shanghai 201203, Peoples R China

[4] Fudan Univ, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China

[5] Fudan Univ, Collaborat Innovat Ctr Brain Sci, Shanghai 200032, Peoples R China

[6] Fudan Univ, Dept Pharmacol, Sch Basic Med Sci, Shanghai 200032, Peoples R China

[7] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[9] Fudan Univ, Huashan Hosp, Dept Integrat Med, Shanghai 200041, Peoples R China

[10] Fudan Univ, Inst Integrat Med, Shanghai 200041, Peoples R China

[11] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[12] Fudan Univ, Zhongshan Hosp, Minhang Branch, Shanghai 201199, Peoples R China

[13] Fudan Univ, Inst Fudan Minghang Acad Hlth Syst, Minghang Hosp, Shanghai 201199, Peoples R China

来源：

ACS NANO | 2019年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

biomimetic nanocarrier; drug delivery; tumor-targeting; drug nanocrystal; glioma; POLYMERIC NANOPARTICLES; CANCER; PEPTIDE; FUNCTIONALIZATION; NANOCARRIERS; DESIGN; SYSTEM;

D O I：

10.1021/acsnano.9b00661

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The safe and efficient delivery of chemotherapeutic agents remains critical to anticancer therapy. Herein, we report on a targeted drug delivery system based upon a modified cell membrane coating technique and drug nanocrystals (NCs). Specifically, red blood cell (RBC) membrane was modified with targeting peptides through a facile insertion method involving avidin biotin interactions. The RBC membrane-coated drug NCs (RBC-NCs) exhibited high drug loading, long-term stability, excellent biocompatibility, and prolonged retention time, all of which make them suitable for effective drug delivery. When modified with the tumor-targeting peptide c(RGDyK), the resulting RGD-RBC-NCs showed superior tumor accumulation and therapeutic efficacy both in mice bearing a subcutaneous tumor as well as orthotropic glioma. RBC-NC therapeutics can be readily generalized to the delivery of various drugs and for the treatment of a wide range of cancers.

引用

页码：5591 / 5601

页数：11

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