Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways

被引:167
作者
Sepulcre, J. [1 ,2 ,3 ]
Masdeu, J. C. [1 ,2 ,3 ]
Goni, J. [2 ,3 ,4 ]
Arrondo, G. [1 ]
de Mendizabal, N. Velez [2 ,3 ,5 ]
Bejarano, B. [1 ]
Villoslada, P. [1 ,2 ,3 ]
机构
[1] Univ Navarra, Dept Neurol & Neurosurg, E-31080 Pamplona, Spain
[2] Univ Navarra, Neuroimmunol Lab, CIMA, Pamplona, Spain
[3] Univ Navarra, CIMA, Neuroimaging Lab, Pamplona, Spain
[4] Univ Navarra, Dept Appl Math & Phys, Pamplona, Spain
[5] Univ Basque Country, Dept Computat Sci & Artificial Intelligence, San Sebastian, Spain
关键词
fatigue; gray matter atrophy; multiple sclerosis; voxel-based morphometry; white matter lesions; QUALITY-OF-LIFE; WORKING-MEMORY; DISABILITY; DEPRESSION; DISEASE; IMPACT; MRI; MS; PERSONALITY; DEFINITION;
D O I
10.1177/1352458508098373
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Fatigue is one of the most frequent and disturbing symptoms in multiple sclerosis (MS), directly affecting the patient's quality of life. However, many questions remain unclear regarding the anatomic brain correlate of MS-related fatigue. Objective To assess the relationship between fatigue and white matter lesion location and gray matter atrophy. Methods In this study, 60 patients with MS were evaluated with the Modified Fatigue Impact Scale and magnetic resonance imaging. Location of white matter lesion was analyzed using a voxel-by-voxel lesion probability mapping approach and gray matter atrophy degree and location using an optimized voxel-based morphometry method. Results We found a correlation between lesion load and fatigue score (T2 lesion load: r = 0.415, P = 0.001; T1 lesion load r = 0.328, P = 0.011). Moreover, fatigue correlated with lesions in the right parietotemporal (periatrial area, juxtaventricular white matter deep in the parietal lobe and callosal forceps) and left frontal (middle-anterior corpus callosum, anterior cingulum and centrum semiovale of the superior and middle frontal gyri) white matter regions (P < 0.001 in all cases). Finally, fatigue score significantly correlated with gray matter atrophy in frontal regions, specifically, the left superior frontal gyrus and bilateral middle frontal gyri (P < 0.001 in all cases). Conclusion Our results suggest that the symptom of fatigue is associated with a disruption of brain networks involved in cognitive/attentional processes. Multiple Sclerosis 2009; 15: 337-344. http://msj.sagepub.com
引用
收藏
页码:337 / 344
页数:8
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