Ligand-Free Silver(I)-Catalyzed Intramolecular Friedel-Crafts Alkylation of Arenes with Allylic Alcohols

被引：38

作者：

Bandini, Marco ^{[1
]}

Eichholzer, Astrid ^{[1
]}

Kotrusz, Peter ^{[1
]}

Tragni, Michele ^{[1
]}

Troisi, Stefano ^{[1
]}

Umani-Ronchi, Achille ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 03期

关键词：

alkylation; aromatic compounds; catalysis; Friedel-Crafts reaction; silver; ELECTRON-RICH ARENES; C-C-BOND; GOLD CATALYSIS; EFFICIENT; ALLYLATION; INDOLES; HYDROARYLATION; SUBSTITUTION; VERSATILE; PHENOLS;

D O I：

10.1002/adsc.200800628

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The silver-catalyzed direct activation of allylic alcohols as electrophilic partners for intramolecular Friedel-Crafts alkylation of arenes is described. Use of silver triflate (AgOTf; 10 mol%) enabled functionalized 1-vinyl-1,2,3,4-tetrahydronaphthalenes and a 4-vinyl-1,2,3,4-tetrahydroisoquinoline to be isolated in good yields with high levels of regiochemistry, under a ligand-free regime.

引用

页码：319 / 324

页数：6

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