Direct C-H bond arylation:: Selective palladium-catalyzed C2-arylation of N-substituted indoles

被引:256
作者
Lane, BS [1 ]
Sames, D [1 ]
机构
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
关键词
D O I
10.1021/ol0490072
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We present a new, practical method by which N-substituted indoles may be selectively arylated in the C2-position with good yields, low catalyst loadings, and a high degree of functional group tolerance. Our investigation found that two competitive processes, namely, the desired cross-coupling and biphenyl formation, were operative in this reaction. A simple kinetic model was formulated that proved to be instructive and provided useful guidelines for reaction optimization; the approach described within may prove to be useful in other catalytic cross-coupling processes.
引用
收藏
页码:2897 / 2900
页数:4
相关论文
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