Fatal liaisons of p53 with Bax and Bak

被引：69

作者：

Perfettini, JL

Kroemer, RT

Kroemer, G

机构：

[1] Inst Gustave Roussy, CNRS, UMR8125, Apoptosis Canc & Immun Lab, F-94805 Villejuif, France

[2] Mol Modeling & Design Pharm, I-20014 Nerviano, MI, Italy

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 05期

关键词：

D O I：

10.1038/ncb0504-386

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

p53 can induce apoptosis through its well defined role as a regulator of transcription, but also by a less well defined transcription-independent mechanism. Two recent studies demonstrate that p53 mediates mitochondrial permeabilization through direct physical interactions with the pro-apoptotic Bcl-2 family members, Bax and Bak.

引用

收藏

页码：386 / 388

页数：3

相关论文

共 15 条

[1] Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis [J].

Bennett, M ;

Macdonald, K ;

Chan, SW ;

Luzio, JP ;

Simari, R ;

Weissberg, P .

SCIENCE, 1998, 282 (5387) :290-293

[2] Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription [J].

Chipuk, JE ;

Maurer, U ;

Green, DR ;

Schuler, M .

CANCER CELL, 2003, 4 (05) :371-381

[3] Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis [J].

Chipuk, JE ;

Kuwana, T ;

Bouchier-Hayes, L ;

Droin, NM ;

Newmeyer, D ;

Schuler, M ;

Green, DR .

SCIENCE, 2004, 303 (5660) :1010-1014

[4] Essential role for caspase-8 in transcription-independent apoptosis triggered by p53 [J].

Ding, HF ;

Lin, YL ;

McGill, G ;

Juo, P ;

Zhu, H ;

Blenis, J ;

Yuan, JY ;

Fisher, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (49) :38905-38911

[5] The codon 72 polymorphic variants of p53 have markedly different apoptotic potential [J].

Dumont, P ;

Leu, JIJ ;

Della Pietra, AC ;

George, DL ;

Murphy, M .

NATURE GENETICS, 2003, 33 (03) :357-365

[6] Mitochondrial control of cell death [J].

Kroemer, G ;

Reed, JC .

NATURE MEDICINE, 2000, 6 (05) :513-519

[7] Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics [J].

Letai, A ;

Bassik, MC ;

Walensky, LD ;

Sorcinelli, MD ;

Weiler, S ;

Korsmeyer, SJ .

CANCER CELL, 2002, 2 (03) :183-192

[8] Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex [J].

Leu, JIJ ;

Dumont, P ;

Hafey, M ;

Murphy, ME ;

George, DL .

NATURE CELL BIOLOGY, 2004, 6 (05) :443-450

[9] Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3 [J].

Lin, BZ ;

Kolluri, SK ;

Lin, F ;

Liu, W ;

Han, YH ;

Cao, XH ;

Dawson, MI ;

Reed, JC ;

Zhang, XK .

CELL, 2004, 116 (04) :527-540

[10] p53 has a direct apoptogenic role at the mitochondria [J].

Mihara, M ;

Erster, S ;

Zaika, A ;

Petrenko, O ;

Chittenden, T ;

Pancoska, P ;

Moll, UM .

MOLECULAR CELL, 2003, 11 (03) :577-590