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Mitochondrial control of cell death

被引：2713
作者：
Kroemer, G
Reed, JC
机构：
[1] Inst Gustave Roussy, CNRS, ULR 1599, F-94805 Villejuif, France
[2] Burnham Inst, La Jolla, CA 92037 USA
来源：
NATURE MEDICINE | 2000年 / 6卷 / 05期
关键词：
D O I：
10.1038/74994
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.
引用
收藏
页码：513 / 519
页数：7
相关论文
共 83 条
  • [1] Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver
    Andreyev, A
    Fiskum, G
    [J]. CELL DEATH AND DIFFERENTIATION, 1999, 6 (09) : 825 - 832
  • [2] Characterization of a silencer element and purification of a silencer protein that negatively regulates the human adenine nucleotide translocator 2 promoter
    Baráth, P
    Albert-Fournier, B
    Luciaková, K
    Nelson, BD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (06) : 3378 - 3384
  • [3] Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis
    Bauer, MKA
    Schubert, A
    Rocks, O
    Grimm, S
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 147 (07) : 1493 - 1501
  • [4] Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
    Berman, SB
    Hastings, TG
    [J]. JOURNAL OF NEUROCHEMISTRY, 1999, 73 (03) : 1127 - 1137
  • [5] Mitochondria and cell death - Mechanistic aspects and methodological issues
    Bernardi, P
    Scorrano, L
    Colonna, R
    Petronilli, V
    Di Lisa, F
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (03): : 687 - 701
  • [6] Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
    Brenner, C
    Cadiou, H
    Vieira, HLA
    Zamzami, N
    Marzo, I
    Xie, ZH
    Leber, B
    Andrews, D
    Duclohier, H
    Reed, JC
    Kroemer, G
    [J]. ONCOGENE, 2000, 19 (03) : 329 - 336
  • [7] Biochemical pathways of caspase activation during apoptosis
    Budihardjo, I
    Oliver, H
    Lutter, M
    Luo, X
    Wang, XD
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 : 269 - 290
  • [8] Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells
    Carri, MT
    Ferri, A
    Battistoni, A
    Famhy, L
    Gabbianelli, R
    Poccia, F
    Rotilio, G
    [J]. FEBS LETTERS, 1997, 414 (02) : 365 - 368
  • [9] Carthy CM, 1999, LAB INVEST, V79, P953
  • [10] Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease
    Casari, G
    De Fusco, M
    Ciarmatori, S
    Zeviani, M
    Mora, M
    Fernandez, P
    De Michele, G
    Filla, A
    Cocozza, S
    Marconi, R
    Dürr, A
    Fontaine, B
    Ballabio, A
    [J]. CELL, 1998, 93 (06) : 973 - 983
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