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Mitochondrial control of cell death

被引：2713
作者：
Kroemer, G
Reed, JC
机构：
[1] Inst Gustave Roussy, CNRS, ULR 1599, F-94805 Villejuif, France
[2] Burnham Inst, La Jolla, CA 92037 USA
来源：
NATURE MEDICINE | 2000年 / 6卷 / 05期
关键词：
D O I：
10.1038/74994
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.
引用
收藏
页码：513 / 519
页数：7
相关论文
共 83 条
  • [41] Translocation of SAPK/JNK to mitochondria and interaction with Bcl-xL in response to DNA damage
    Kharbanda, S
    Saxena, S
    Yoshida, K
    Pandey, P
    Kaneki, M
    Wang, QZ
    Cheng, K
    Chen, YN
    Campbell, A
    Sudha, T
    Yuan, ZM
    Narula, J
    Weichselbaum, R
    Nalin, C
    Kufe, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) : 322 - 327
  • [42] Cyclosporin A and its nonimmunosuppressive analogue N-Me-Val-4-cyclosporin A mitigate glucose/oxygen deprivation-induced damage to rat cultured hippocampal neurons
    Khaspekov, L
    Friberg, H
    Halestrap, A
    Viktorov, I
    Wieloch, T
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (09) : 3194 - 3198
  • [43] Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
    Kirsch, DG
    Doseff, A
    Chau, BN
    Lim, DS
    de Souza-Pinto, NC
    Hansford, R
    Kastan, MB
    Lazebnik, YA
    Hardwick, JM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) : 21155 - 21161
  • [44] Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
    Klivenyi, P
    Ferrante, RJ
    Matthews, RT
    Bogdanov, MB
    Klein, AM
    Andreassen, OA
    Mueller, G
    Wermer, M
    Kaddurah-Daouk, R
    Beal, MF
    [J]. NATURE MEDICINE, 1999, 5 (03) : 347 - 350
  • [45] Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
    Kostic, V
    JacksonLewis, V
    deBilbao, F
    DuboisDauphin, M
    Przedborski, S
    [J]. SCIENCE, 1997, 277 (5325) : 559 - 562
  • [46] Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin
    Koutnikova, H
    Campuzano, V
    Foury, F
    Dolle, P
    Cazzalini, O
    Koenig, M
    [J]. NATURE GENETICS, 1997, 16 (04) : 345 - 351
  • [47] Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
    Krajewski, S
    Krajewska, M
    Ellerby, LM
    Welsh, K
    Xie, ZH
    Deveraux, QL
    Salvesen, GS
    Bredesen, DE
    Rosenthal, RE
    Fiskum, G
    Reed, JC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) : 5752 - 5757
  • [48] The mitochondrial death/life regulator in apoptosis and necrosis
    Kroemer, G
    Dallaporta, B
    Resche-Rigon, M
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 1998, 60 : 619 - 642
  • [49] Ultrastructural and biochemical observations on the early changes in apoptotic epithelial cells of the rat prostate induced by castration
    Kwong, J
    Choi, HL
    Huang, Y
    Chan, FL
    [J]. CELL AND TISSUE RESEARCH, 1999, 298 (01) : 123 - 136
  • [50] Mitochondrial permeability transition during hypothermic to normothermic reperfusion in rat liver demonstrated by the protective effect of cyclosporin A
    LeDucq, N
    Delmas-Beauvieux, MC
    Bourdel-Marchasson, I
    Dufour, S
    Gallis, JL
    Canioni, P
    Diolez, P
    [J]. BIOCHEMICAL JOURNAL, 1998, 336 : 501 - 506
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