Syntheses of Carbocyclic Uracil Polyoxin C Analogs: Application of Pd(0)/InI-Allylation of 4-Acetoxy-2-azetidinone

被引：20

作者：

Cesario, Cara ^{[1
]}

Miller, Marvin J. ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 15期

关键词：

BETA-LACTAM ANTIBIOTICS; CIS-HYDROXYLATION; CHITIN SYNTHETASE; ALPHA-EPIMER; NUCLEOSIDES; NIKKOMYCINS; APOPTOSIS; ROUTE; CELLS; TUMOR;

D O I：

10.1021/jo900861x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carbocyclic uracil polyoxin C analogs are prepared from an acylnitroso-derived hetero Diels-Alder cycloadduct in fewer than nine steps, Pd(0)/InI-mediated allylation of 4-acetoxy-2-azetidinone is used to install the beta-amino acid side chain at the C-5' position of the carbocycle.

引用

页码：5730 / 5733

页数：4

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