Parathyroid hormone may be a cancer promoter - an explanation for the decrease in cancer risk associated with ultraviolet light, calcium, and vitamin D

被引:65
作者
McCarty, MF [1 ]
机构
[1] Nutr 21AMBI, San Diego, CA USA
关键词
D O I
10.1054/mehy.1999.0880
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Epidemiological studies reporting an inverse association between sunlight exposure and risk for cancers of the breast, colon, and prostate, have not yet been explained. Since ultraviolet (UV) light promotes dermal vitamin D generation, studies suggesting that dietary calcium and vitamin D may likewise have cancer-preventive activity are potentially of relevance. UV light, calcium, and vitamin D have the common property of suppressing parathyroid hormone (PTH) production; these considerations raise the possibility that PTH may have promotional activity for certain cancers. PTH might function indirectly in this regard, by increasing hepatic production of the progression growth factor IGF-I, a likely cancer promoter. A more direct role is suggested by recent evidence that many cancers express receptors for PTH/PTH-related protein; these receptors mediate co-mitogenic and/or pro-invasive signals in some cancers. High risk for previous or concurrent neoplasms has been reported in patients with parathyroid adenomas. In light of the increase in cancer risk associated with hypertension, it is notable that PTH levels are typically increased in salt-sensitive hypertensives. Prospective case-control studies examining serum PTH in relation to subsequent cancer risk appear warranted. (C) 2000 Harcourt Publishers Ltd.
引用
收藏
页码:475 / 482
页数:8
相关论文
共 126 条
  • [91] NEWMARK HL, 1992, CANCER RES, V52, pS2067
  • [92] NEWMARK HL, 1994, ADV EXP MED BIOL, V364, P109
  • [93] NEWMARK HL, 1984, J NATL CANCER I, V72, P1323
  • [94] THE NATURE AND SIGNIFICANCE OF THE RELATIONSHIP BETWEEN URINARY SODIUM AND URINARY CALCIUM IN WOMEN
    NORDIN, BEC
    NEED, AG
    MORRIS, HA
    HOROWITZ, M
    [J]. JOURNAL OF NUTRITION, 1993, 123 (09) : 1615 - 1622
  • [95] NORMAN AW, PRESENT KNOWLEDGE NU, P120
  • [96] G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells
    Offermanns, S
    IidaKlein, A
    Segre, GV
    Simon, MI
    [J]. MOLECULAR ENDOCRINOLOGY, 1996, 10 (05) : 566 - 574
  • [97] Peehl DM, 1997, PROSTATE, V31, P47
  • [98] INHIBITION OF DIETARY FAT-PROMOTED COLON CARCINOGENESIS IN RATS BY SUPPLEMENTAL CALCIUM OR VITAMIN-D3
    PENCE, BC
    BUDDINGH, F
    [J]. CARCINOGENESIS, 1988, 9 (01) : 187 - 190
  • [99] ROLE OF CALCIUM IN COLON-CANCER PREVENTION - EXPERIMENTAL AND CLINICAL-STUDIES
    PENCE, BC
    [J]. MUTATION RESEARCH, 1993, 290 (01): : 87 - 95
  • [100] Pritchard RS, 1996, CANCER EPIDEM BIOMAR, V5, P897